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Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others〔Additional names include ''trimethadione embryopathy'' and ''trimethadione syndrome''.〕) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.〔(Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes ) - Retrieved January 2007〕 Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,〔(Fetal trimethadione syndrome on the ORD website. ) Retrieved January 2007〕 meaning it affects less than 200,000 individuals in the United States.〔(NIH's Office of Rare Diseases ) Retrieved January 2007〕 The fetal loss rate while using trimethadione has been reported to be as high as 87%.〔(Teratology and Drug Use During Pregnancy ) Retrieved January 2007〕 == Characteristics == Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.〔〔(The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome ) Retrieved January 2007〕 * Cranial and facial abnormalities which include; microcephaly, midfacial flattening, V-shaped eyebrows and a short nose * Cardiovascular abnormalities * Absent kidney and ureter * Meningocele, a birth defect of the spine * Omphalocele, a birth defect where portions of the abdominal contents project into the umbilical cord * A delay in mental and physical development 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fetal trimethadione syndrome」の詳細全文を読む スポンサード リンク
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